Thomas Ala, MD

Professor, Neurology
Neurology

    About me

    Dr. Ala has been with SIU Medicine since 1999.  He is certified with the American Board of Psychiatry and Neurology and specializes in the evaluation and treatment of patients who have cognitive disorders, including Alzheimer's disease and other dementing illnesses.  Dr. Ala has been a member of the team that plans and implements Risk and Preention/Healthy Brain Aging Programs which are comprised of evening events for the community and all-day symposiums for healthcare providers.  The programs summarize recent research on risk and protective factors for Alzheimer's disease and discuss the latest recommendations regarding how to lower one's risk for dementia.  Dr. Ala is responsible for the clinical aspects of the SIU Memory and Aging Network sites.  This program provides patients who have concerns of possible Alzheimer’s disease and related disorders the opportunity to be evaluated closer to home rather than have to travel to specialized centers in St. Louis, Chicago, or Indianapolis.  Thirty-two sites servicing 93 Illinois counties outside of the Chicago area have been recruited and trained in this program, including hospitals, clinics, health departments, mental health and counseling centers, and organizations that serve the elderly.

    Gender

    Male

    Education & training

    Positions
    Medical Director of the Alzheimer's Center
    Neurologist
    Board Certifications
    Neurology
    Medical School
    University of Minnesota, Minneapolis, MN
    Residency
    University of Minnesota, Minneapolis, MN - Neurology
    Fellowship
    Regions Hospital, St. Paul, MN - Neuropathology

    Research

    Research Interests
    Caregiving issues in Alzheimer's disease. Clinical and Neuropathological research in Alzheimer's disease, Lewy Body Dementia, Vascular Dementia, and Other Dementing Illnesses. New Treatments for Alzheimer's Disease. Behavioral Neurology. Memory loss.

    Publications

    Jones G, Tabassum V, Zarow GJ, Ala T. The inability of older adults to recall their drugs and medical conditions. Drugs Aging. 2015;32:329-336;  

    Pyo G, Ala T, Kyrouac GA, Verhulst SJ. A validity study of the Working Group's Autobiographical Memory Test for individuals with moderate to severe intellectual disability. Res Dev Disabil. 2011;32:70-74. PMID: 20875945; 

    Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX. Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis. 2010;22:393-399. PMID: 20847431; 

    Pyo G, Ala T, Kyrouac GA, Verhulst SJ. A pilot study of a test for visual recognition memory in adults with moderate to severe intellectual disability. Res Dev Disabil. 2010;31:1475–1480. PMID: 20630702; 

    Elble RJ, Dubinsky RM, Ala T. Alzheimer’s disease and essential tremor finally meet. (Editorial). Mov Disord. 2007;22:1525-1527. PMID: 17557351; 

    Pyo G, Elble RJ, Ala T, Markwell SJ. The characteristics of patients with Uncertain/Mild Cognitive Impairment on the Alzheimer Disease Assessment Scale-Cognitive subscale. Alzheimer Dis Assoc Disord. 2006;20:16-22. PMID: 16493231;

    Ala TA, Berck LG, Popovich AM. Using the telephone to call for help and caregiver awareness in Alzheimer disease. Alzheimer Dis Assoc Disord. 2005;19:79-84. PMID: 15942325; 

    Ala TA, Berck LG, Popovich AM. Knowledge of personal information and caregiver awareness in Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2005;20:119-125. PMID: 15844758

    Clinical trials

    Trial
    Neuroscience Institute

    GN40040: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study of MTAU9937A in Patients with Moderate Alzheimer's Disease

    Active not recruiting

    GN40040:  The purpose of this study is to assess the clinical efficacy, safety, pharmacokinetics, and pharmacodynamics of MTAU9937A in patients with moderate Alzheimer's disease.

    Trial
    Neurology

    Annovis - A Randomized, Double-Blind, Placebo-Controlled, Dose-ranging, Multicenter Study of Buntanetap in Participants with Mild to Moderate Alzheimer's Disease

    Active recruiting

    The purpose of this study is to assess the efficacy and safety of Buntanetap in participants with mild to moderate Alzheimer's Disease participants.

    Trial
    Neurology

    Annovis - A Randomized, Double-Blind, Placebo-Controlled, Dose-ranging, Multicenter Study of Buntanetap in Participants with Mild to Moderate Alzheimer's Disease

    Active recruiting

    The purpose of this study is to assess the efficacy and safety of Buntanetap in participants with mild to moderate Alzheimer's Disease participants.

    Trial
    Neurology

    Open-Label Extension of Studies ATH-1017-AD-0201 and ATH-1017-AD-0202 in Subjects with Mild to Moderate Alzheimer's Disease

    Active not recruiting

    ATH-1017-AD-203: The purpose of this study is to determine the safety and tolerability of ATH-1017 in patients with mild to moderate Alzheimer's disease.

    Trial
    Neurology

    Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

    Active recruiting
    This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
    Trial
    Neurology

    Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

    Active recruiting
    This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
    Trial
    Neurology

    Lilly: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

    Active not recruiting

    I5T-MC-AACI:  The purpose of this study is to assess the effect of donanemab versus placebo on clinical regression in participants with early symptomatic Alzheimer's disease with presence of low-medium tau pathology.

    Trial
    Neurology

    Lilly: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

    Active not recruiting

    I5T-MC-AACI:  The purpose of this study is to assess the effect of donanemab versus placebo on clinical regression in participants with early symptomatic Alzheimer's disease with presence of low-medium tau pathology.

    Trial
    Neurology

    Roche: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of MTAU9937A in Patients with Moderate Alzheimer's Disease

    Active not recruiting

    The purpose of this study is to assess the clinical efficacy, safety, pharmacokinetics, and pharmacodynamics of MTAU9937A in patients with moderate Alzheimer's disease.

    Trial
    Neurology

    Roche: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of MTAU9937A in Patients with Moderate Alzheimer's Disease

    Active not recruiting

    The purpose of this study is to assess the clinical efficacy, safety, pharmacokinetics, and pharmacodynamics of MTAU9937A in patients with moderate Alzheimer's disease.

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