Clinical trials and research studies

The purpose of this study is to see if seltorexant (JNJ-42847922) as an add-on treatment to current antidepressant is effective for treating patients with major depressive disorder (MDD) with and without sleep problems (such as difficulty falling asleep, staying asleep or poor sleep).

The purpose of this study is to evaluate the long-term safety, tolerability, and effectiveness of PF-06651600(Ritlecitinib) in adult and adolescent (12 years and older) participants with Alopecia Areata.

The purpose of the clinical study is to compare the effectiveness of IBP-9414 treatment against placebo in preventing necrotizing enterocolitis in premature infants.

 

Treatments: Prevention of necrotizing enterocolitis in premature infants

The purpose of this study is to determine if the study drug, inhaled nitric oxide (iNO), when given and breathed through an investigational study device, the INOpulse, may help treat patients at risk for pulmonary hypertension-pulmonary fibrosis. Another purpose of this study is to determine if using the INOpulse delivery device (drug and device combination) improves the levels of moderate to vigorous physical activity (for example walking, climbing stairs, household chores and cleaning and, exercise and hobbies), as measured by actigraphy (a non-invasive way to monitor rest/activity).

PROSPECT:  This is an observational study and is designed to describe the clinical outcomes and the burden of disease in PD patients with motor fluctuations not adequately controlled by current PD medications.

The purpose of this study is to assess the safety and effectiveness of the GORE® EXCLUDER® Conformable AAA Endoprosthesis (Study Device) when used for the treatment of Abdominal Aortic Aneurysms (AAA).

ATH-1017-AD-201: The purpose of this study is to compare the effects, good or bad, of ATH-1017 on patients with mild to moderate Alzheimer's Disease.

PURPOSE: This is a biological sample collection study aimed at developing an early diagnostic tool for endometrial and ovarian cancer. The investigators are studying the relationship between estrogen driven gynecological cancers, inflammation and the microbiome. Patients who have been diagnosed with endometrial cancer or undergo presurgical evaluation for suspicion of ovarian cancer who are scheduled for a hysterectomy, bilateral oophorectomy and/or salpingectomy are eligible. Control patients undergoing gynecological surgery for benign indications are also being recruited.

This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.

The purpose of the study is to demonstrate the safety and effectiveness of the BioVentrix Revivent TC System for the treatment of LV antero-septal aneurysms/scars in patients with symptomatic heart failure.