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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • Active, not recruiting (7)
  • Active, recruiting (20)
  • Inactive, not recruiting (1)

Treatment

  • Abdominal Aortic Aneurysm (1)
  • Alzheimer's Disease (5)
  • Congestive Heart Failure (1)
  • Dementia (1)
  • Depression (1)
  • Diabetes (1)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (4)
  • Male Infertility and Sexual Dysfunction (1)
  • Muscular Dystrophy (1)
  • Parkinson's Disease (3)
  • Psoriasis (1)
  • Stroke (1)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Alzheimer's Center (3)
  • Cardiothoracic Surgery (1)
  • Internal Medicine (1)
  • Neurology (7)
  • Neuroscience Institute (1)
  • Neurosurgery (1)
  • Psychiatry (1)
  • Pulmonary and Critical Care (1)
  • Surgery (1)
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Filter Results

Activity Status

  • Active, not recruiting (7)
  • Active, recruiting (20)
  • Inactive, not recruiting (1)

Treatment

  • Abdominal Aortic Aneurysm (1)
  • Alzheimer's Disease (5)
  • Congestive Heart Failure (1)
  • Dementia (1)
  • Depression (1)
  • Diabetes (1)
  • Heart Disease (1)
  • High Blood Pressure (Hypertension) (4)
  • Male Infertility and Sexual Dysfunction (1)
  • Muscular Dystrophy (1)
  • Parkinson's Disease (3)
  • Psoriasis (1)
  • Stroke (1)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Alzheimer's Center (3)
  • Cardiothoracic Surgery (1)
  • Internal Medicine (1)
  • Neurology (7)
  • Neuroscience Institute (1)
  • Neurosurgery (1)
  • Psychiatry (1)
  • Pulmonary and Critical Care (1)
  • Surgery (1)
Showing: 28 Results
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Trial
Psychiatry

A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia

Active recruiting

The purpose of this study is to see if seltorexant (JNJ-42847922) as an add-on treatment to current antidepressant is effective for treating patients with major depressive disorder (MDD) with and without sleep problems (such as difficulty falling asleep, staying asleep or poor sleep).

Contact: Oladele (Dickson) Owasoyo phone217-545-7231 emailoowasoyo94@siumed.edu
Trial
Dermatology

A PHASE 3 OPEN-LABEL, MULTI-CENTER, LONG-TERM STUDY INVESTIGATING THE SAFETY AND EFFICACY OF PF-06651600 IN ADULT AND ADOLESCENT PARTICIPANTS WITH ALOPECIA AREATA

Active not recruiting

The purpose of this study is to evaluate the long-term safety, tolerability, and effectiveness of PF-06651600(Ritlecitinib) in adult and adolescent (12 years and older) participants with Alopecia Areata.

Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
Trial
Pediatrics

A Randomized, Double Blind, Parallel-group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IBP-9414 in Premature Infants 500-1500g Birth Weight in the Prevention of Necrotizing Enterocolitis - The Connection Study

Active recruiting

The purpose of the clinical study is to compare the effectiveness of IBP-9414 treatment against placebo in preventing necrotizing enterocolitis in premature infants.

Treatments: Prevention of necrotizing enterocolitis in premature infants

Contact: Erin Bauer phone217-545-6955 emailebauer38@siumed.edu
Trial
Pulmonary and Critical Care

A randomized, double-blind, placebo-controlled dose escalation and verification clinical study to assess the safety and efficacy of pulsed, inhaled nitric oxide in subjects at risk of pulmonary hypertension associated with pulmonary fibrosis on long term oxygen therapy

Active recruiting
The purpose of this study is to determine if the study drug, inhaled nitric oxide (iNO), when given and breathed through an investigational study device, the INOpulse, may help treat patients at risk for pulmonary hypertension-pulmonary fibrosis. Another purpose of this study is to determine if using the INOpulse delivery device (drug and device combination) improves the levels of moderate to vigorous physical activity (for example walking, climbing stairs, household chores and cleaning and, exercise and hobbies), as measured by actigraphy (a non-invasive way to monitor rest/activity).
Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
Trial
Neurology

AbbVie: A prospective observational study to evaluate the clinical outcomes and burden of disease of PD patients with motor fluctuations not adequately controlled by current PD medications.

Active not recruiting

PROSPECT:  This is an observational study and is designed to describe the clinical outcomes and the burden of disease in PD patients with motor fluctuations not adequately controlled by current PD medications.

Contact: Sara Boarman phone217-545-6829 emailsboarman93@siumed.edu
Trial
Vascular Surgery

Assessment of the GORE® EXCLUDER® Conformable AAA Endoprosthesis in the Treatment of Abdominal Aortic Aneurysms: AAA 13-03

Active recruiting

The purpose of this study is to assess the safety and effectiveness of the GORE® EXCLUDER® Conformable AAA Endoprosthesis (Study Device) when used for the treatment of Abdominal Aortic Aneurysms (AAA).

Contact: Kristal Adams phone217-545-7812 emailkadams@siumed.edu
Trial
Neurology

Athira: A Randomized, Placebo-Controlled, Double-Blind, Dose-Ranging Study to Evaluate Safety and Efficacy of ATH-1017 Treatment in Alzheimer’s Dementia Patients

Active recruiting

ATH-1017-AD-201: The purpose of this study is to compare the effects, good or bad, of ATH-1017 on patients with mild to moderate Alzheimer's Disease.

Contact: Sara Boarman phone217-545-6829 emailsboarman93@siumed.edu
Trial
Neurology

Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

Active recruiting
This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
Contact: Stephanie Kohlrus phone217-545-3013 emailskohlrus@siumed.edu
Trial
Cardiothoracic Surgery

Clinical Study of the BioVentrix TC System for the Treatment of Left Ventricular Aneurysm

Active recruiting

The purpose of the study is to demonstrate the safety and effectiveness of the BioVentrix Revivent TC System for the treatment of LV antero-septal aneurysms/scars in patients with symptomatic heart failure.

Contact: Katie Mottershaw phone217-545-7387 emailkmottershaw33@siumed.edu
Trial
Dermatology

Corrona Psoriasis (PSO) Registry

Active recruiting

The objective of the Corrona Psoriasis Registry is to create a national database of patients with psoriasis. Data collected will be used to study the  disease and to evaluate the effectiveness and safety of medications approved for the treatment of psoriasis.

Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
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