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clinical trials

Clinical trials and research studies

At SIU Medicine, our researchers perform clinical trials and research studies with the aim of translating findings into new, more effective treatments.
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Activity Status

  • Active, not recruiting (5)
  • Active, recruiting (9)

Treatment

  • (-) Alzheimer's Disease (5)
  • (-) High Blood Pressure (Hypertension) (4)
  • (-) Parkinson's Disease (3)
  • (-) Psoriasis (1)
  • (-) Stroke (1)
  • Abdominal Aortic Aneurysm (1)
  • Congestive Heart Failure (1)
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  • Male Infertility and Sexual Dysfunction (1)
  • Muscular Dystrophy (1)
  • Ovarian Cancer (1)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Alzheimer's Center (3)
  • Internal Medicine (1)
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  • Neuroscience Institute (1)
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Filter Results

Activity Status

  • Active, not recruiting (5)
  • Active, recruiting (9)

Treatment

  • (-) Alzheimer's Disease (5)
  • (-) High Blood Pressure (Hypertension) (4)
  • (-) Parkinson's Disease (3)
  • (-) Psoriasis (1)
  • (-) Stroke (1)
  • Abdominal Aortic Aneurysm (1)
  • Congestive Heart Failure (1)
  • Dementia (1)
  • Depression (1)
  • Diabetes (1)
  • Endometrial Cancer (1)
  • Endometriosis (1)
  • Heart Disease (1)
  • Male Infertility and Sexual Dysfunction (1)
  • Muscular Dystrophy (1)
  • Ovarian Cancer (1)
  • Transcranial Magnetic Stimulation (TMS) (1)

Department

  • Alzheimer's Center (3)
  • Internal Medicine (1)
  • Neurology (6)
  • Neuroscience Institute (1)
  • Pulmonary and Critical Care (1)
Showing: 14 Results
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Trial
Pulmonary and Critical Care

A randomized, double-blind, placebo-controlled dose escalation and verification clinical study to assess the safety and efficacy of pulsed, inhaled nitric oxide in subjects at risk of pulmonary hypertension associated with pulmonary fibrosis on long term oxygen therapy

Active recruiting
The purpose of this study is to determine if the study drug, inhaled nitric oxide (iNO), when given and breathed through an investigational study device, the INOpulse, may help treat patients at risk for pulmonary hypertension-pulmonary fibrosis. Another purpose of this study is to determine if using the INOpulse delivery device (drug and device combination) improves the levels of moderate to vigorous physical activity (for example walking, climbing stairs, household chores and cleaning and, exercise and hobbies), as measured by actigraphy (a non-invasive way to monitor rest/activity).
Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
Trial
Neurology

AbbVie: A prospective observational study to evaluate the clinical outcomes and burden of disease of PD patients with motor fluctuations not adequately controlled by current PD medications.

Active not recruiting

PROSPECT:  This is an observational study and is designed to describe the clinical outcomes and the burden of disease in PD patients with motor fluctuations not adequately controlled by current PD medications.

Contact: Sara Boarman phone217-545-6829 emailsboarman93@siumed.edu
Trial
Neurology

Athira: A Randomized, Placebo-Controlled, Double-Blind, Dose-Ranging Study to Evaluate Safety and Efficacy of ATH-1017 Treatment in Alzheimer’s Dementia Patients

Active recruiting

ATH-1017-AD-201: The purpose of this study is to compare the effects, good or bad, of ATH-1017 on patients with mild to moderate Alzheimer's Disease.

Contact: Sara Boarman phone217-545-6829 emailsboarman93@siumed.edu
Trial
Neurology

Caregiver Characteristics That May Predict When Patients With Alzheimer Disease Are Placed in Long Term Care Facilities

Active recruiting
This research will be conducted by the SIU Memory and Aging Network (MAN), which comprises 38 sites that evaluate and treat patients with dementia throughout non-metropolitan Illinois.  AD patients and their caregivers who are living in private homes will be recruited.  Primary outcome measures will be the ratings of the caregiver’s physical status (grip strength, walking speed, and score on the Timed Up-and-Go Test11 and the rating of the caregiver’s chronic medical illness burden using the Cumulative Illness Rating Scale (Geriatric).12,13  The patient and caregiver dyad is required.
Contact: Stephanie Kohlrus phone217-545-3013 emailskohlrus@siumed.edu
Trial
Dermatology

Corrona Psoriasis (PSO) Registry

Active recruiting

The objective of the Corrona Psoriasis Registry is to create a national database of patients with psoriasis. Data collected will be used to study the  disease and to evaluate the effectiveness and safety of medications approved for the treatment of psoriasis.

Contact: Rebecca Coughlin phone217-545-7321 emailrcoughlin59@siumed.edu
Trial
Neurology

Lilly: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease

Active not recruiting

I5T-MC-AACI: Alzheimer’s is a disease that attacks the brain, causing problems with memory, thinking, and behavior.  Symptoms usually develop slowly and get worse over time, eventually making daily tasks impossible. Although we don’t know the exact cause, researchers found out that the two proteins called tau and amyloid are building up in brains of people with Alzheimer’s disease even before they have any symptoms.

Contact: Barbara Lokaitis phone217-545-9737 emailblokaitis@siumed.edu
Trial
Neurology

Phase 2b/3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of Dipraglurant (ADX48621) for the Treatment of Dyskinesia in Patients with Parkinson's Disease Receiving Levodopa-based Therapy With or Without Concomitant Dopaminergic Medications

Active recruiting

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of the investigational drug, dipraglurant (ADX48621), in subjects with Parkinson’s disease (PD) and levodopa-induced dyskinesia (LID).

 

Contact: Sara Boarman phone217-545-6829 emailSara Boarman
Trial
Neurology

Portola: A Randomized Clinical Trial of Andexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor XA Inhibitor

Active not recruiting

ANNEXa-1 (18-513): This is a randomized, multicenter clinical trial designed to determine the efficacy and safety of andexanet compared to usual care in patients presenting with acute intracerebral hemorrhage within 6 hours of symptom onset (from the baseline scan) and within 15 hours of taking an oral FXa inhibitor (from randomization). The study will use a prospective, randomized, open-label design, as it is unfeasible to blind the Investigator to the treatment assignment given the many potential therapeutic options available under usual care treatment.

Contact: Barbara Lokaitis phone217-545-9737 emailblokaitis@siumed.edu
Trial
Internal Medicine

RADIANCE Continued Access Protocol (CAP): A study of the ReCor Medical Paradise System in Clinical Hypertension

Active recruiting

PURPOSE: This purpose of this clinical trial is to find out if a medical device called the Paradise Renal Denervation System
can lower blood pressure in patients who have hypertension

Contact: Emily Starkey phone217-545-7616 emailestarkey74@siumed.edu
Trial
Internal Medicine

REFRESH: A Phase 3, Double-blind, Placebo-controlled and Open-label Efficacy and Long-term Safety Study of Firibastat (QGC001) Administered Orally, Once Daily, for Up to 48 Weeks in Patients with Difficult-to-treat/Resistant Hypertension

Active recruiting

PURPOSE: The purpose of this clinical trial is to assess the effects of firibastat on blood pressure, in patients with difficult-to-treat and/or treatment-resistant hypertension

Contact: Emily Starkey phone217-545-7616 emailestarkey74@siumed.edu
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